Question: If you were in space, someone is floating 'upside down' and someone is 'upright', would they feel any different? I've put ' on the 2 words because there isn't really direction in space. :/

Alex Haragan answered on 11 Jun 2018:

Short answer: No.
The reason you float in space is, of course, because there is not enough (or none, depending on how you think about it) gravity to keep you forced down, the way it does on Earth.
Your body has evolved to work on a planet with gravity keeping us the ground. As a result our bodies are designed to be upright, and we all know that if you stand on your hands or dangle upside down you quickly get light-headed, blood rushes to your head, and eventually you’d pass out.
This is all because our bodies are designed to move blood up from your legs using muscles and valves – but from our head we just rely on gravity.
No gravity and it doesn’t really matter what way round you are!
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Another major difference is our muscles. Our muscles are constantly working hard because of gravity, fighting to keep us upright against gravity. In space – that constant force is lost. Which is why astronauts lose lots of their muscles if they are in space for a long time. Most will not be able to even walk when they return to Earth – they need to do special exercises to get used to gravity again!
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As for being in space – you are correct, “up” and “down” have no meaning – so it feels the same no matter what way round you are.